In order to get the most out of any convention experience, it makes sense to plan ahead. As much as possible, check the websites of the convention, the creators, the vendors, and other organizations to learn what parts of the show you most want to see. Take note of what you need to do to accomplish these goals, whether it be wait in long lines, get special tickets, win a raffle, whatever, and prepare to jump through those hoops. For example, at some conventions, the best strategy to see a popular panel is to suffer through an unpopular one occurring before it. Sidenote: I'd like to thank The Legend of Neil for being the really popular panel right after mine in San Diego last year, thereby filling my room.
Okay, so once you've figured out what you want to do and what you need to do it, plan to fail. Comic convention schedules rarely fall into place as easily in reality as they do on paper. Creators are late to signings, panels run long, lines are longer than expected, panel rooms fill up. There are a hundred ways you could be blocked from your plan. So while you're setting your agenda for the convention, prepare a secondary agenda. Have a plan B for everything. That way you're not left standing at the edge of the convention hall wondering what you should do until the next item on your list rolls around.
Even if this agenda is as simple as a list of vendors you want to visit, anything that keeps you from wasting convention floor time will benefit you. Many a convention regret stems from wandering aimlessly through a con, only to realize after it's over that there were five or six things you should have accomplished during that time.
Plan ahead, and plan ahead for your first plan to fall through.